CHEMGRID MOLECULE CARD
XYLAZINE
XYLAZINE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01501200
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01501200
- Molecular formula
- C12H16N2S
- InChIKey
- BPICBUSOMSTKRF-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Xylazine
Stored SMILES
Cc1cccc(C)c1NC1SCCCN=1Matched external records: PubChem 5707
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Adra1b · Adrenergic receptor alpha-1 | ChEMBL | No stored yeast mapping |
| Adra2c · Adrenergic receptor alpha-2 | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL | No stored yeast mapping |
| CYP2D6 · Cytochrome P450 2D6 | ChEMBL | No stored yeast mapping |
| CYP3A4 · Cytochrome P450 3A4 | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| RAB9A · Ras-related protein Rab-9A | ChEMBL | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| TSHR · Thyrotropin receptor | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| PMP22 · Peripheral myelin protein 22 | ChEMBL analogue | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL analogue | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete XYLAZINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.