CHEMGRID MOLECULE CARD
ZAPRINAST
ZAPRINAST in ChemGrid: 192 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01501199
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01501199
- Molecular formula
- C13H13N5O2
- CAS registry number
- 37762-06-4
- Libraries
- Spectrum, SPECMTS3
- Other recorded names
- Zaprinast
Stored SMILES
CCCOc1ccccc1C1NC(=O)c2nnnc2N=1Matched external records: PubChem 135399235
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
192 measurements across 192 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Phosphodiesterase 4 [CHEMBL2093863] | ChEMBL | No stored yeast mapping |
| Phosphodiesterase 4 [CHEMBL2094267] | ChEMBL | No stored yeast mapping |
| Phosphodiesterase 6 | ChEMBL | No stored yeast mapping |
| ABCC5 · ATP-binding cassette sub-family C member 5 | ChEMBL | No stored yeast mapping |
| Gpr35 · G protein-coupled receptor GPR35 | ChEMBL | No stored yeast mapping |
| GPR35 · G-protein coupled receptor 35 [CHEMBL1293267] | ChEMBL | No stored yeast mapping |
| Gpr35 · G-protein coupled receptor 35 [CHEMBL2390813] | ChEMBL | No stored yeast mapping |
| PDE2A · cGMP-dependent 3',5'-cyclic phosphodiesterase | ChEMBL | No stored yeast mapping |
| PDE3B · Phosphodiesterase 3B | ChEMBL | No stored yeast mapping |
| PDE5A · cGMP-specific 3',5'-cyclic phosphodiesterase [CHEMBL1827] | ChEMBL | No stored yeast mapping |
| PDE5A · cGMP-specific 3',5'-cyclic phosphodiesterase [CHEMBL2304402] | ChEMBL | No stored yeast mapping |
| PDE5A · cGMP-specific 3',5'-cyclic phosphodiesterase [CHEMBL3478] | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete ZAPRINAST research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.