CHEMGRID MOLECULE CARD
SPIPERONE
SPIPERONE in ChemGrid: 205 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01501152
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01501152
- Molecular formula
- C23FH26N3O2
- CAS registry number
- 749-02-0
- InChIKey
- DKGZKTPJOSAWFA-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Spiperone
Stored SMILES
Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1Matched external records: PubChem 5265
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| whi5 | SPECMTS3 | 4932 | -4.38 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Adra1b · Alpha-1B adrenergic receptor | ChEMBL | No stored yeast mapping |
| Csn2 · Beta-casein | ChEMBL | RPN6 YDL097C (ortholog_one2many) |
| Drd2 · D(2) dopamine receptor | ChEMBL | No stored yeast mapping |
| DRD3 · D(3) dopamine receptor | ChEMBL | No stored yeast mapping |
| DRD4 · D(4) dopamine receptor | ChEMBL | No stored yeast mapping |
| Drd5 · Dopamine receptor | ChEMBL | No stored yeast mapping |
| HTR2A · 5-hydroxytryptamine receptor 2A | ChEMBL | No stored yeast mapping |
| Htr2b · Serotonin 2 (5-HT2) receptor | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| HTR7 · 5-hydroxytryptamine receptor 7 | ChEMBL analogue | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL analogue | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL analogue | No stored yeast mapping |
| NPSR1 · Neuropeptide S receptor | ChEMBL analogue | No stored yeast mapping |
| PMP22 · Peripheral myelin protein 22 | ChEMBL analogue | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL analogue | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete SPIPERONE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.