CHEMGRID MOLECULE CARD
RANITIDINE
RANITIDINE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01501151
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01501151
- Molecular formula
- C13H22N4O3S
- CAS registry number
- 66357-35-5
- InChIKey
- VMXUWOKSQNHOCA-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Ranisen
Stored SMILES
[O-][N+](=O)C=C(NC)NCCSCc1oc(CN(C)C)cc1Matched external records: PubChem 5039
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ACHE · Acetylcholinesterase | ChEMBL | No stored yeast mapping |
| ATP4A · Potassium-transporting ATPase | ChEMBL | ENA5 YDR038C (ortholog_many2many); ENA2 YDR039C (ortholog_many2many); ENA1 YDR040C (ortholog_many2many); CCC2 YDR270W (ortholog_many2many); PMA1 YGL008C (ortholog_many2many); PMR1 YGL167C (ortholog_many2many); YOR291W (ortholog_many2many); PMA2 YPL036W (ortholog_many2many) |
| CHRM2 · Muscarinic acetylcholine receptor M2 | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL | No stored yeast mapping |
| HRH2 · Histamine H2 receptor | ChEMBL | No stored yeast mapping |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| NFKB1 · Nuclear factor NF-kappa-B p105 subunit | ChEMBL | No stored yeast mapping |
| Pmp22 · Peripheral myelin protein 22 | ChEMBL | No stored yeast mapping |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| ampC · Beta-lactamase | ChEMBL analogue | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL analogue | No stored yeast mapping |
| RAD52 · DNA repair protein RAD52 homolog | ChEMBL analogue | RAD59 YDL059C (ortholog_one2many); RAD52 YML032C (ortholog_one2many) |
| rep · Replicase polyprotein 1ab | ChEMBL analogue | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL analogue | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete RANITIDINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.