CHEMGRID MOLECULE CARD
CAPSAICIN
CAPSAICIN in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01501128
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01501128
- Molecular formula
- C18H27NO3
- CAS registry number
- 404-86-4
- InChIKey
- YKPUWZUDDOIDPM-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- E-CAPSAICIN; Capsaicin
Stored SMILES
COc1cc(CNC(=O)CCCCC=CC(C)C)ccc1OMatched external records: PubChem 1548943
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Vanilloid receptor | ChEMBL | No stored yeast mapping |
| CNR1 · Cannabinoid receptor 1 | ChEMBL | No stored yeast mapping |
| CNR2 · Cannabinoid receptor 2 | ChEMBL | No stored yeast mapping |
| DRD3 · D(3) dopamine receptor | ChEMBL | No stored yeast mapping |
| KDM1A · Lysine-specific histone demethylase 1A | ChEMBL | No stored yeast mapping |
| Pmp22 · Peripheral myelin protein 22 | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| TRPM8 · Transient receptor potential cation channel subfamily M member 8 | ChEMBL | No stored yeast mapping |
| TRPV1 · Transient receptor potential cation channel subfamily V member 1 [CHEMBL4794] | ChEMBL | YVC1 YOR087W (ortholog_one2many) |
| Trpv1 · Transient receptor potential cation channel subfamily V member 1 [CHEMBL5102] | ChEMBL | YVC1 YOR087W (ortholog_one2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete CAPSAICIN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.