CHEMGRID MOLECULE CARD

PUROMYCIN HYDROCHLORIDE

PUROMYCIN HYDROCHLORIDE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE01501105

Explore activity & SONAR

Chemical structure of PUROMYCIN HYDROCHLORIDE — Stored molecular structure

205Screened assays

0Significant assay responses

6Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE01501105
Molecular formula: C22Cl2H31N7O5
InChIKey: MKSVFGKWZLUTTO-UHFFFAOYSA-N
Libraries: Spectrum, SPECMTS3, Spectrum_ED
Other recorded names: Puromycin dihydrochloride from Streptomyces alboniger powder

Stored SMILES

Cl.Cl.COc1ccc(CC(N)C(=O)NC2C(O)C(OC2CO)n2cnc3c(ncnc23)N(C)C)cc1

Matched external records: PubChem 16757772

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
GMNN · Geminin	ChEMBL	No stored yeast mapping
HTT · Huntingtin	ChEMBL	No stored yeast mapping
Pmp22 · Peripheral myelin protein 22	ChEMBL	No stored yeast mapping
Rorc · Nuclear receptor ROR-gamma	ChEMBL	No stored yeast mapping
SMN1 · Survival motor neuron protein	ChEMBL	No stored yeast mapping
TP53 · Cellular tumor antigen p53	ChEMBL	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete PUROMYCIN HYDROCHLORIDE research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.