CHEMGRID MOLECULE CARD
3-HYDROXYFLAVONE
3-HYDROXYFLAVONE in ChemGrid: 205 screened assays, 98 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01501012
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01501012
- Molecular formula
- C15H10O3
- CAS registry number
- 577-85-5
- InChIKey
- HVQAJTFOCKOKIN-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Flavonol
Stored SMILES
OC1C(=O)c2ccccc2OC=1c1ccccc1Matched external records: PubChem 11349
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 98 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| pep5 | SPECMTS3 | 4932 | -48.33 |
| ssb2 | SPECMTS3 | 4932 | -46.21 |
| fet3 | SPECMTS3 | 4932 | -38.23 |
| rpn1 | SPECMTS3 | 4932 | -37.22 |
| hsp104 | SPECMTS3 | 4932 | -36.97 |
| drs2 | SPECMTS3 | 4932 | -35.84 |
| arl3 | SPECMTS3 | 4932 | -34.79 |
| lat1 | SPECMTS3 | 4932 | -34.43 |
| paf1 | SPECMTS3 | 4932 | -32.35 |
| tpk1 | SPECMTS3 | 4932 | -32.14 |
| faa2 | SPECMTS3 | 4932 | -30.04 |
| kem1 | SPECMTS3 | 4932 | -30.01 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| ATXN2 · Ataxin-2 | ChEMBL | No stored yeast mapping |
| CA1 · Carbonic anhydrase 1 | ChEMBL | No stored yeast mapping |
| CYP1B1 · Cytochrome P450 1B1 | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| PKM · Pyruvate kinase PKM | ChEMBL | CDC19 YAL038W (ortholog_many2many); PYK2 YOR347C (ortholog_many2many) |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| ALOX12 · Polyunsaturated fatty acid lipoxygenase ALOX12 | ChEMBL analogue | No stored yeast mapping |
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL analogue | No stored yeast mapping |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL analogue | No stored yeast mapping |
| CASP1 · Caspase-1 | ChEMBL analogue | No stored yeast mapping |
| CASP7 · Caspase-7 | ChEMBL analogue | No stored yeast mapping |
| fabI · Enoyl-acyl-carrier protein reductase | ChEMBL analogue | No stored yeast mapping |
| FTL · Ferritin light chain | ChEMBL analogue | No stored yeast mapping |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL analogue | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL analogue | YJR119C (ortholog_one2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 3-HYDROXYFLAVONE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.