CHEMGRID MOLECULE CARD
ETHAVERINE HYDROCHLORIDE
ETHAVERINE HYDROCHLORIDE in ChemGrid: 616 screened assays, 40 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01501000
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01501000
- Molecular formula
- C24ClH30NO4
- InChIKey
- UPUDVKWQBVIKBG-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, SpectrumTMP, Spectrum_ED
- Other recorded names
- Ethaverine Hydrochloride
Stored SMILES
Cl.CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCCMatched external records: PubChem 5702159
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
616 measurements across 616 distinct library–species–strain assays; 40 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| HAL24h | SpectrumTMP | 4932 | -27.96 |
| DHA18h | SpectrumTMP | 4932 | -18.98 |
| FAS18h | SpectrumTMP | 4932 | -18.30 |
| NIF18h | SpectrumTMP | 4932 | -16.19 |
| AVM18h | SpectrumTMP | 4932 | -13.84 |
| wPYR18 | SpectrumTMP | 4932 | -10.43 |
| DAM18h | SpectrumTMP | 4932 | -9.41 |
| wFIS20 | SpectrumTMP | 4932 | -9.31 |
| wFIS22 | SpectrumTMP | 4932 | -8.45 |
| SAM18h | SpectrumTMP | 4932 | -8.24 |
| DHA24h | SpectrumTMP | 4932 | -8.20 |
| AVM24h | SpectrumTMP | 4932 | -8.05 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| PDE4D · 3',5'-cyclic-AMP phosphodiesterase 4D | ChEMBL | No stored yeast mapping |
| POLK · DNA polymerase kappa | ChEMBL | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| USP1 · Ubiquitin carboxyl-terminal hydrolase 1 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many); UBP8 YMR223W (ortholog_many2many); UBP2 YOR124C (ortholog_many2many) |
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| dnaB · Replicative DNA helicase DnaB | ChEMBL analogue | No stored yeast mapping |
| fba · Fructose-bisphosphate aldolase | ChEMBL analogue | SMI1 YGR229C (ortholog_one2many) |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL analogue | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL analogue | No stored yeast mapping |
| PDE10A · cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | ChEMBL analogue | No stored yeast mapping |
| recA · Protein RecA | ChEMBL analogue | RAD51 YER095W (ortholog_one2one) |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete ETHAVERINE HYDROCHLORIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.