CHEMGRID MOLECULE CARD
4`-HYDROXYFLAVANONE
4`-HYDROXYFLAVANONE in ChemGrid: 101 screened assays, 77 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500908
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500908
- Molecular formula
- C15H12O3
- InChIKey
- ZLHVIYHWWQYJID-UHFFFAOYSA-N
- Libraries
- Spectrum
- Other recorded names
- 4'-Hydroxyflavanone
Stored SMILES
Oc1ccc(cc1)C1CC(=O)c2ccccc2O1Matched external records: PubChem 165506
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
101 measurements across 101 distinct library–species–strain assays; 77 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| mck1 | Spectrum | 4932 | -35.06 |
| tif3 | Spectrum | 4932 | -25.81 |
| pex11 | Spectrum | 4932 | -19.70 |
| ser1 | Spectrum | 4932 | -16.82 |
| vps1 | Spectrum | 4932 | -15.97 |
| SLT2 | Spectrum | 4932 | -14.61 |
| cdc73 | Spectrum | 4932 | -13.33 |
| BCK2 | Spectrum | 4932 | -13.11 |
| rad52 | Spectrum | 4932 | -12.82 |
| NBP2 | Spectrum | 4932 | -12.57 |
| mcm21 | Spectrum | 4932 | -12.47 |
| BEM2 | Spectrum | 4932 | -12.45 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Ache · Acetylcholinesterase | ChEMBL | No stored yeast mapping |
| Adora1 · Adenosine receptor A1 | ChEMBL | No stored yeast mapping |
| ADORA3 · Adenosine receptor A3 | ChEMBL | No stored yeast mapping |
| FTL · Ferritin light chain | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL | NCR1 YPL006W (ortholog_one2one) |
| PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor | ChEMBL | No stored yeast mapping |
| RAB9A · Ras-related protein Rab-9A | ChEMBL | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| ALOX12 · Polyunsaturated fatty acid lipoxygenase ALOX12 | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL analogue | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL analogue | No stored yeast mapping |
| CYP19A1 · Aromatase | ChEMBL analogue | No stored yeast mapping |
| DPP4 · Dipeptidyl peptidase 4 | ChEMBL analogue | DAP2 YHR028C (ortholog_one2one) |
| FTL · Ferritin light chain | ChEMBL analogue | No stored yeast mapping |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| MAOB · Amine oxidase [flavin-containing] B | ChEMBL analogue | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL analogue | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL analogue | No stored yeast mapping |
| PDK1 · [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial | ChEMBL analogue | PKH1 YDR490C (ortholog_one2many); YGL059W (ortholog_one2many); PKH2 YOL100W (ortholog_one2many) |
| PIN1 · Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | ChEMBL analogue | ESS1 YJR017C (ortholog_one2one) |
| POLI · DNA polymerase iota | ChEMBL analogue | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 4`-HYDROXYFLAVANONE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.