CHEMGRID MOLECULE CARD
NORHARMAN
NORHARMAN in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500871
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500871
- Molecular formula
- C11H8N2
- CAS registry number
- 244-63-3
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Beta-Carboline
Stored SMILES
n1c2ccccc2c2ccncc12Matched external records: PubChem 64961
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Chitinase | ChEMBL | No stored yeast mapping |
| GABA-A receptor; anion channel [CHEMBL1907607] | ChEMBL | No stored yeast mapping |
| GABA-A receptor; anion channel [CHEMBL2093872] | ChEMBL | No stored yeast mapping |
| AURKA · Aurora kinase A | ChEMBL | No stored yeast mapping |
| DYRK1A · Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ChEMBL | No stored yeast mapping |
| IDO1 · Indoleamine 2,3-dioxygenase 1 | ChEMBL | No stored yeast mapping |
| IKBKB · Inhibitor of nuclear factor kappa-B kinase subunit beta | ChEMBL | No stored yeast mapping |
| MAOA · Amine oxidase [flavin-containing] A | ChEMBL | No stored yeast mapping |
| MAOB · Amine oxidase [flavin-containing] B | ChEMBL | No stored yeast mapping |
| PIM1 · Serine/threonine-protein kinase pim-1 | ChEMBL | PIM1 YBL022C (ortholog_one2many) |
| TDO2 · Tryptophan 2,3-dioxygenase | ChEMBL | No stored yeast mapping |
| GALR2 · Galanin receptor type 2 | ChEMBL analogue | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL analogue | YJR119C (ortholog_one2many) |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MTOR · Serine/threonine-protein kinase mTOR | ChEMBL analogue | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL analogue | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| THPO · Thrombopoietin | ChEMBL analogue | No stored yeast mapping |
| TP53 · Cellular tumor antigen p53 | ChEMBL analogue | No stored yeast mapping |
| TSHR · Thyrotropin receptor | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete NORHARMAN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.