CHEMGRID MOLECULE CARD
HARMINE
HARMINE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500867
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500867
- Molecular formula
- C13H12N2O
- CAS registry number
- 442-51-3
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Harmine
Stored SMILES
COc1ccc2c(nc3c(C)nccc32)c1Matched external records: PubChem 5280953
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ABCG2 · Broad substrate specificity ATP-binding cassette transporter ABCG2 | ChEMBL | SNQ2 YDR011W (ortholog_many2many); PDR15 YDR406W (ortholog_many2many); PDR11 YIL013C (ortholog_many2many); YNR070W (ortholog_many2many); AUS1 YOR011W (ortholog_many2many); PDR5 YOR153W (ortholog_many2many); PDR10 YOR328W (ortholog_many2many); PDR12 YPL058C (ortholog_many2many) |
| Clk1 · Dual specificity protein kinase CLK1 [CHEMBL1075280] | ChEMBL | No stored yeast mapping |
| CLK1 · Dual specificity protein kinase CLK1 [CHEMBL4224] | ChEMBL | No stored yeast mapping |
| Clk4 · Dual specificity protein kinase CLK4 [CHEMBL1075283] | ChEMBL | YAK1 YJL141C (ortholog_many2many); KNS1 YLL019C (ortholog_many2many) |
| CLK4 · Dual specificity protein kinase CLK4 [CHEMBL4203] | ChEMBL | YAK1 YJL141C (ortholog_many2many); KNS1 YLL019C (ortholog_many2many) |
| DYRK1A · Dual specificity tyrosine-phosphorylation-regulated kinase 1A [CHEMBL2292] | ChEMBL | No stored yeast mapping |
| Dyrk1a · Dual specificity tyrosine-phosphorylation-regulated kinase 1A [CHEMBL5508] | ChEMBL | No stored yeast mapping |
| DYRK1B · Dual specificity tyrosine-phosphorylation-regulated kinase 1B | ChEMBL | No stored yeast mapping |
| HDAC1 · Histone deacetylase 1 | ChEMBL | No stored yeast mapping |
| MAOA · Amine oxidase [flavin-containing] A | ChEMBL | No stored yeast mapping |
| NISCH · Nischarin | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete HARMINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.