CHEMGRID MOLECULE CARD
HARMANE
HARMANE in ChemGrid: 104 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500866
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500866
- Molecular formula
- C12H10N2
- CAS registry number
- 486-84-0
- Libraries
- SPECMTS3, Spectrum_ED
- Other recorded names
- Harman
Stored SMILES
Cc1nccc2c1nc1ccccc12Matched external records: PubChem 5281404
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
104 measurements across 104 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ACHE · Acetylcholinesterase [CHEMBL220] | ChEMBL | No stored yeast mapping |
| ache · Acetylcholinesterase [CHEMBL4078] | ChEMBL | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| DYRK1A · Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ChEMBL | No stored yeast mapping |
| MAOA · Amine oxidase [flavin-containing] A | ChEMBL | No stored yeast mapping |
| TDO2 · Tryptophan 2,3-dioxygenase | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete HARMANE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.