CHEMGRID MOLECULE CARD

CARYOPHYLLENE [t(-)]

CARYOPHYLLENE [t(-)] in ChemGrid: 205 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE01500842

Explore activity & SONAR

Chemical structure of CARYOPHYLLENE [t(-)] — Stored molecular structure

205Screened assays

1Significant assay responses

5Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE01500842
Molecular formula: C14H22
CAS registry number: 87-44-5
InChIKey: INOSMXBKABLUIL-UHFFFAOYSA-N
Libraries: Spectrum, SPECMTS3, Spectrum_ED
Other recorded names: CARYOPHYLLENE [t (-)]; 5,9,9-Trimethyl-2-methylidenebicyclo[6.2.0]dec-4-ene

Stored SMILES

CC1CCC2C(CC2(C)C)C(=C)CC=1

Matched external records: PubChem 5153010

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
trk1	SPECMTS3	4932	-5.07

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
CNR2 · Cannabinoid receptor 2	ChEMBL	No stored yeast mapping
HDAC6 · Protein deacetylase HDAC6	ChEMBL	HDA1 YNL021W (ortholog_one2one)
MEN1 · Menin/Histone-lysine N-methyltransferase MLL	ChEMBL	No stored yeast mapping
PPARA · Peroxisome proliferator-activated receptor alpha	ChEMBL	No stored yeast mapping
rep · Replicase polyprotein 1ab	ChEMBL	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete CARYOPHYLLENE [t(-)] research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.