CHEMGRID MOLECULE CARD

BRUCINE

BRUCINE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE01500822

Explore activity & SONAR

Chemical structure of BRUCINE — Stored molecular structure

205Screened assays

0Significant assay responses

3Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE01500822
Molecular formula: C23H26N2O4
InChIKey: RRKTZKIUPZVBMF-UHFFFAOYSA-N
Libraries: Spectrum, SPECMTS3, Spectrum_ED
Other recorded names: Brucin

Stored SMILES

COc1cc2N3C4C5C(CC3=O)OCC=C3CN6CCC4(C6CC53)c2cc1OC

Matched external records: PubChem 220520

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
KAT2A · Histone acetyltransferase KAT2A	ChEMBL analogue	BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many)
MEN1 · Menin/Histone-lysine N-methyltransferase MLL	ChEMBL analogue	No stored yeast mapping
rep · Replicase polyprotein 1ab	ChEMBL analogue	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete BRUCINE research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.