CHEMGRID MOLECULE CARD
ADENINE
ADENINE in ChemGrid: 616 screened assays, 34 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500807
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500807
- Molecular formula
- C5H5N5
- CAS registry number
- 73-24-5
- Libraries
- Spectrum, SPECMTS3, SpectrumTMP, Spectrum_ED
- Other recorded names
- Adenine
Stored SMILES
Nc1ncnc2ncnc12Matched external records: PubChem 190
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
616 measurements across 616 distinct library–species–strain assays; 34 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| SLT2 | Spectrum | 4932 | -29.96 |
| vps1 | Spectrum | 4932 | -26.98 |
| FUR4 | Spectrum | 4932 | -21.11 |
| mck1 | Spectrum | 4932 | -17.39 |
| CNB1 | Spectrum | 4932 | -13.23 |
| BEM2 | Spectrum | 4932 | -11.17 |
| ypt6-2nd | Spectrum | 4932 | -10.90 |
| ric1-2nd | Spectrum | 4932 | -10.01 |
| arf1 | Spectrum | 4932 | -9.84 |
| cdc73 | Spectrum | 4932 | -9.72 |
| pex11 | Spectrum | 4932 | -9.61 |
| BNI4 | Spectrum | 4932 | -9.42 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| AURKA · Aurora kinase A | ChEMBL | No stored yeast mapping |
| AURKB · Aurora kinase B | ChEMBL | IPL1 YPL209C (ortholog_one2many) |
| CYP3A4 · Cytochrome P450 3A4 | ChEMBL | No stored yeast mapping |
| ITK · Tyrosine-protein kinase ITK/TSK | ChEMBL | No stored yeast mapping |
| JAK3 · Tyrosine-protein kinase JAK3 | ChEMBL | No stored yeast mapping |
| MAP3K5 · Mitogen-activated protein kinase kinase kinase 5 | ChEMBL | No stored yeast mapping |
| MAPKAPK2 · MAP kinase-activated protein kinase 2 | ChEMBL | No stored yeast mapping |
| PDK1 · [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial | ChEMBL | PKH1 YDR490C (ortholog_one2many); YGL059W (ortholog_one2many); PKH2 YOL100W (ortholog_one2many) |
| PIK3CD · Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | ChEMBL | No stored yeast mapping |
| PIK3CG · Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | ChEMBL | No stored yeast mapping |
| ROCK1 · Rho-associated protein kinase 1 | ChEMBL | No stored yeast mapping |
| SGK1 · Serine/threonine-protein kinase Sgk1 | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete ADENINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.