CHEMGRID MOLECULE CARD
LIOTHYRONINE
LIOTHYRONINE in ChemGrid: 205 screened assays, 10 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500778
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500778
- Molecular formula
- C15H12I3NO4
- CAS registry number
- 3130-96-9, 6893-02-3
- InChIKey
- AUYYCJSJGJYCDS-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- RATHYRONINE; Liothyronine; DL-Triiodothyronine
Stored SMILES
NC(Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=OMatched external records: PubChem 5920 PubChem 861
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 10 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| lat1 | SPECMTS3 | 4932 | -18.23 |
| mck1 | Spectrum | 4932 | -16.46 |
| bck1 | SPECMTS3 | 4932 | -6.91 |
| cdc73 | Spectrum | 4932 | -5.78 |
| vps1 | Spectrum | 4932 | -5.44 |
| qcr8 | SPECMTS3 | 4932 | -4.81 |
| hhf1 | SPECMTS3 | 4932 | -4.65 |
| tif3 | Spectrum | 4932 | -4.30 |
| tpk1 | SPECMTS3 | 4932 | -4.26 |
| mcm21 | Spectrum | 4932 | -4.09 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADORA1 · Adenosine receptor A1 | ChEMBL | No stored yeast mapping |
| CNR1 · Cannabinoid receptor 1 | ChEMBL | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL | No stored yeast mapping |
| F2 · Prothrombin | ChEMBL | No stored yeast mapping |
| HRH2 · Histamine H2 receptor | ChEMBL | No stored yeast mapping |
| HTR6 · 5-hydroxytryptamine receptor 6 | ChEMBL | No stored yeast mapping |
| PCNA · Proliferating cell nuclear antigen | ChEMBL | No stored yeast mapping |
| PPARG · Peroxisome proliferator-activated receptor gamma | ChEMBL | No stored yeast mapping |
| TDG · G/T mismatch-specific thymine DNA glycosylase | ChEMBL | No stored yeast mapping |
| THRA · Thyroid hormone receptor alpha | ChEMBL | No stored yeast mapping |
| THRB · Thyroid hormone receptor beta | ChEMBL | No stored yeast mapping |
| THRB · Thyroid hormone receptor beta [CHEMBL1947] | ChEMBL | No stored yeast mapping |
| Thrb · Thyroid hormone receptor beta [CHEMBL3917] | ChEMBL | No stored yeast mapping |
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL analogue | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL analogue | No stored yeast mapping |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL analogue | No stored yeast mapping |
| MIF · Macrophage migration inhibitory factor | ChEMBL analogue | No stored yeast mapping |
| POLK · DNA polymerase kappa | ChEMBL analogue | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| USP1 · Ubiquitin carboxyl-terminal hydrolase 1 | ChEMBL analogue | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many); UBP8 YMR223W (ortholog_many2many); UBP2 YOR124C (ortholog_many2many) |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL analogue | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
| VDR · Vitamin D3 receptor | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete LIOTHYRONINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.