CHEMGRID MOLECULE CARD
EUPATORIN
EUPATORIN in ChemGrid: 101 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500731
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500731
- Molecular formula
- C18H16O7
- InChIKey
- KLAOKWJLUQKWIF-UHFFFAOYSA-N
- Libraries
- Spectrum
- Other recorded names
- Eupatorin
Stored SMILES
COc1ccc(cc1O)C1Oc2cc(OC)c(OC)c(O)c2C(=O)C=1Matched external records: PubChem 97214
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
101 measurements across 101 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| rad50 | Spectrum | 4932 | -4.37 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| AURKA · Aurora kinase A | ChEMBL | No stored yeast mapping |
| AURKB · Aurora kinase B | ChEMBL | IPL1 YPL209C (ortholog_one2many) |
| FLT3 · Receptor-type tyrosine-protein kinase FLT3 | ChEMBL | No stored yeast mapping |
| KDR · Vascular endothelial growth factor receptor 2 | ChEMBL | No stored yeast mapping |
| Cruzipain | ChEMBL analogue | No stored yeast mapping |
| ABCC1 · Multidrug resistance-associated protein 1 | ChEMBL analogue | No stored yeast mapping |
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL analogue | No stored yeast mapping |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL analogue | No stored yeast mapping |
| CA12 · Carbonic anhydrase 12 | ChEMBL analogue | No stored yeast mapping |
| CA4 · Carbonic anhydrase 4 | ChEMBL analogue | No stored yeast mapping |
| CA7 · Carbonic anhydrase 7 | ChEMBL analogue | No stored yeast mapping |
| CSNK2B · Casein kinase 2 | ChEMBL analogue | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL analogue | No stored yeast mapping |
| CYP1B1 · Cytochrome P450 1B1 | ChEMBL analogue | No stored yeast mapping |
| DPP4 · Dipeptidyl peptidase 4 | ChEMBL analogue | DAP2 YHR028C (ortholog_one2one) |
| FTO · Alpha-ketoglutarate-dependent dioxygenase FTO | ChEMBL analogue | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL analogue | HDA1 YNL021W (ortholog_one2one) |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL analogue | No stored yeast mapping |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL analogue | No stored yeast mapping |
| IP6K2 · Inositol hexakisphosphate kinase 2 | ChEMBL analogue | No stored yeast mapping |
| IPMK · Inositol polyphosphate multikinase | ChEMBL analogue | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL analogue | YJR119C (ortholog_one2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| MKNK1 · MAP kinase-interacting serine/threonine-protein kinase 1 | ChEMBL analogue | No stored yeast mapping |
| PIM1 · Serine/threonine-protein kinase pim-1 | ChEMBL analogue | PIM1 YBL022C (ortholog_one2many) |
| POLK · DNA polymerase kappa | ChEMBL analogue | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| PTPRS · Receptor-type tyrosine-protein phosphatase S | ChEMBL analogue | No stored yeast mapping |
| RECQL · ATP-dependent DNA helicase Q1 | ChEMBL analogue | No stored yeast mapping |
| SLC16A1 · Monocarboxylate transporter 1 | ChEMBL analogue | MCH4 YOL119C (ortholog_many2many); MCH5 YOR306C (ortholog_many2many) |
| TTR · Transthyretin | ChEMBL analogue | No stored yeast mapping |
First 30 of 32 target records; open the interactive profile for further evidence.
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete EUPATORIN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.