CHEMGRID MOLECULE CARD
CIMETIDINE
CIMETIDINE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500684
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500684
- Molecular formula
- C10H16N6S
- CAS registry number
- 51481-61-9
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Cimetidine
Stored SMILES
CNC(NCCSCc1ncnc1C)=NC#NMatched external records: PubChem 2756
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Potassium-transporting ATPase | ChEMBL | No stored yeast mapping |
| CNR1 · Cannabinoid receptor 1 | ChEMBL | No stored yeast mapping |
| CYP3A4 · Cytochrome P450 3A4 | ChEMBL | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL | No stored yeast mapping |
| HRH2 · Histamine H2 receptor [CHEMBL1941] | ChEMBL | No stored yeast mapping |
| HRH2 · Histamine H2 receptor [CHEMBL2882] | ChEMBL | No stored yeast mapping |
| Hrh2 · Histamine H2 receptor [CHEMBL4654] | ChEMBL | No stored yeast mapping |
| HTR6 · 5-hydroxytryptamine receptor 6 | ChEMBL | No stored yeast mapping |
| HTR7 · 5-hydroxytryptamine receptor 7 | ChEMBL | No stored yeast mapping |
| Slc22a1 · Solute carrier family 22 member 1 | ChEMBL | PHO84 YML123C (ortholog_one2many) |
| Slc22a3 · Solute carrier family 22 member 3 | ChEMBL | PHO84 YML123C (ortholog_one2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete CIMETIDINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.