CHEMGRID MOLECULE CARD
TRIFLUOPERAZINE HYDROCHLORIDE
TRIFLUOPERAZINE HYDROCHLORIDE in ChemGrid: 205 screened assays, 178 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500591
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500591
- Molecular formula
- C21Cl2F3H26N3S
- InChIKey
- BXDAOUXDMHXPDI-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Trifluoperazine Hydrochloride
Stored SMILES
Cl.Cl.CN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1Matched external records: PubChem 66064
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 178 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| elg1 | Spectrum | 4932 | -58.09 |
| BY4741 | SPECMTS3 | 4932 | -57.56 |
| set2 | Spectrum | 4932 | -54.74 |
| tub3 | Spectrum | 4932 | -54.55 |
| pex11 | Spectrum | 4932 | -54.18 |
| paf1 | SPECMTS3 | 4932 | -54.14 |
| nat1 | SPECMTS3 | 4932 | -54.09 |
| hsp104 | SPECMTS3 | 4932 | -53.72 |
| mad1 | Spectrum | 4932 | -53.51 |
| CIN2 | Spectrum | 4932 | -53.11 |
| clb2 | Spectrum | 4932 | -53.10 |
| snc1 | SPECMTS3 | 4932 | -53.04 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL | HDA1 YNL021W (ortholog_one2one) |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL analogue | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| GLA · Alpha-galactosidase A | ChEMBL analogue | No stored yeast mapping |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL analogue | HDA1 YNL021W (ortholog_one2one) |
| Impa1 · Inositol monophosphatase 1 | ChEMBL analogue | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL analogue | No stored yeast mapping |
| NOX1 · NADPH oxidase 1 | ChEMBL analogue | FRE7 YOL152W (ortholog_many2many); FRE5 YOR384W (ortholog_many2many) |
| NPSR1 · Neuropeptide S receptor | ChEMBL analogue | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL analogue | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete TRIFLUOPERAZINE HYDROCHLORIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.