CHEMGRID MOLECULE CARD
TOLNAFTATE
TOLNAFTATE in ChemGrid: 616 screened assays, 15 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500583
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500583
- Molecular formula
- C19H17NOS
- CAS registry number
- 2398-96-1
- InChIKey
- FUSNMLFNXJSCDI-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, SpectrumTMP, Spectrum_ED
- Other recorded names
- Tolnaftate
Stored SMILES
CN(C(=S)Oc1ccc2ccccc2c1)c1cccc(C)c1Matched external records: PubChem 5510
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
616 measurements across 616 distinct library–species–strain assays; 15 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| rgp1 | SPECMTS3 | 4932 | 8.53 |
| ric1 | Spectrum | 4932 | 5.79 |
| SAM18h | SpectrumTMP | 4932 | 5.13 |
| YPT6 | Spectrum | 4932 | 4.89 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADORA1 · Adenosine receptor A1 | ChEMBL | No stored yeast mapping |
| ADORA3 · Adenosine receptor A3 | ChEMBL | No stored yeast mapping |
| ADRB1 · Beta-1 adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRB2 · Beta-2 adrenergic receptor | ChEMBL | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| CBX1 · Chromobox protein homolog 1 | ChEMBL | No stored yeast mapping |
| CHRNA4 · Neuronal acetylcholine receptor subunit alpha-4 | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| CYP2C19 · Cytochrome P450 2C19 | ChEMBL | DIT2 YDR402C (ortholog_one2many) |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| Gabra1 · Gamma-aminobutyric acid receptor subunit alpha-1 | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| Grin1 · Glutamate receptor ionotropic, NMDA 1 | ChEMBL | No stored yeast mapping |
| HTR2B · 5-hydroxytryptamine receptor 2B | ChEMBL | No stored yeast mapping |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| NR1I2 · Nuclear receptor subfamily 1 group I member 2 | ChEMBL | No stored yeast mapping |
| OPRK1 · Kappa-type opioid receptor | ChEMBL | No stored yeast mapping |
| Pmp22 · Peripheral myelin protein 22 | ChEMBL | No stored yeast mapping |
| SLC29A1 · Equilibrative nucleoside transporter 1 | ChEMBL | FUN26 YAL022C (ortholog_one2many) |
| SLC6A3 · Sodium-dependent dopamine transporter | ChEMBL | No stored yeast mapping |
| vpr · Aberrant vpr protein | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete TOLNAFTATE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.