CHEMGRID MOLECULE CARD

STREPTOZOSIN

STREPTOZOSIN in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE01500543

Explore activity & SONAR

Chemical structure of STREPTOZOSIN — Stored molecular structure

205Screened assays

0Significant assay responses

3Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE01500543
Molecular formula: C8H15N3O7
CAS registry number: 18883-66-4
InChIKey: ZSJLQEPLLKMAKR-UHFFFAOYSA-N
Libraries: Spectrum, SPECMTS3, Spectrum_ED
Other recorded names: 1-Methyl-1-Nitroso-3-(2,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-3-Yl)Urea

Stored SMILES

CN(N=O)C(=O)NC1C(O)OC(CO)C(O)C1O

Matched external records: PubChem 5300

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
CYP2C19 · Cytochrome P450 2C19	ChEMBL	DIT2 YDR402C (ortholog_one2many)
CYP2D6 · Cytochrome P450 2D6	ChEMBL	No stored yeast mapping
lef · Lethal factor	ChEMBL	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete STREPTOZOSIN research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.