CHEMGRID MOLECULE CARD
PIROXICAM
PIROXICAM in ChemGrid: 205 screened assays, 12 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500491
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500491
- Molecular formula
- C15H13N3O4S
- CAS registry number
- 36322-90-4
- InChIKey
- QYSPLQLAKJAUJT-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Piroxicam
Stored SMILES
CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=OMatched external records: PubChem 54676228
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 12 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| lat1 | SPECMTS3 | 4932 | -10.52 |
| trk1 | SPECMTS3 | 4932 | -9.90 |
| rpa49 | SPECMTS3 | 4932 | 9.24 |
| mck1 | Spectrum | 4932 | -7.63 |
| spt3 | SPECMTS3 | 4932 | -7.44 |
| BY4743 | Spectrum_ED | 4932 | -7.27 |
| pfk2 | SPECMTS3 | 4932 | -7.03 |
| tif3 | Spectrum | 4932 | -5.42 |
| nup100 | Spectrum | 4932 | -5.13 |
| bmi1 | Spectrum | 4932 | -4.39 |
| qcr8 | SPECMTS3 | 4932 | -4.22 |
| hsp104 | SPECMTS3 | 4932 | -4.01 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL | No stored yeast mapping |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| NFKB1 · Nuclear factor NF-kappa-B p105 subunit | ChEMBL | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL | No stored yeast mapping |
| PTGS1 · Prostaglandin G/H synthase 1 | ChEMBL | No stored yeast mapping |
| Ptgs2 · Cyclooxygenase | ChEMBL | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL analogue | No stored yeast mapping |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL analogue | YJR119C (ortholog_one2many) |
| NFKB1 · Nuclear factor NF-kappa-B p105 subunit | ChEMBL analogue | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL analogue | No stored yeast mapping |
| PTGS1 · Prostaglandin G/H synthase 1 | ChEMBL analogue | No stored yeast mapping |
| Ptgs2 · Cyclooxygenase | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete PIROXICAM research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.