CHEMGRID MOLECULE CARD
NYSTATIN
NYSTATIN in ChemGrid: 205 screened assays, 175 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500446
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500446
- Molecular formula
- C47H75NO17
- CAS registry number
- 114-90-9
- InChIKey
- VQOXZBDYSJBXMA-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- 33-((3-Amino-3,6-dideoxyhexopyranosyl)oxy)-1,3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo(33.3.1)nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid
Stored SMILES
CC1OC(=O)CC(O)CC(O)CC(O)CCC(O)C(O)CC2(O)CC(O)C(C(CC(OC3OC(C)C(O)C(N)C3O)C=CC=CC=CC=CCCC=CC=CC(C)C(O)C1C)O2)C(O)=OMatched external records: PubChem 4568
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 175 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| BY4743 | Spectrum_ED | 4932 | -76.91 |
| nup100 | Spectrum | 4932 | -64.50 |
| BY4741-3rd | Spectrum_ED | 4932 | -57.75 |
| kgd1 | Spectrum | 4932 | -55.31 |
| elg1 | Spectrum | 4932 | -54.96 |
| mdh1 | Spectrum | 4932 | -54.32 |
| YKL085W | Spectrum | 4932 | -54.32 |
| tub3 | Spectrum | 4932 | -53.43 |
| KRE1 | Spectrum | 4932 | -51.96 |
| pex11 | Spectrum | 4932 | -51.91 |
| rvs167 | Spectrum | 4932 | -51.88 |
| CIN8 | Spectrum | 4932 | -51.51 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CTDSP1 · Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | ChEMBL analogue | PSR2 YLR019W (ortholog_one2many) |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL analogue | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL analogue | YJR119C (ortholog_one2many) |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL analogue | No stored yeast mapping |
| POLH · DNA polymerase eta | ChEMBL analogue | RAD30 YDR419W (ortholog_one2one) |
| POLI · DNA polymerase iota | ChEMBL analogue | No stored yeast mapping |
| POLK · DNA polymerase kappa | ChEMBL analogue | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| SNCA · Alpha-synuclein | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| WRN · Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete NYSTATIN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.