CHEMGRID MOLECULE CARD
MICONAZOLE NITRATE
MICONAZOLE NITRATE in ChemGrid: 205 screened assays, 204 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500413
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500413
- Molecular formula
- C18Cl4H15N3O4
- InChIKey
- MCCACAIVAXEFAL-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Miconazole Nitrate
Stored SMILES
[O-][N+](O)=O.Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1Matched external records: PubChem 68553
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 204 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| BY4743 | Spectrum_ED | 4932 | -75.88 |
| nup100 | Spectrum | 4932 | -63.61 |
| elg1 | Spectrum | 4932 | -59.19 |
| BY4741 | SPECMTS3 | 4932 | -57.88 |
| BY4741-3rd | Spectrum_ED | 4932 | -56.80 |
| tub3 | Spectrum | 4932 | -56.11 |
| nat1 | SPECMTS3 | 4932 | -55.83 |
| set2 | Spectrum | 4932 | -55.23 |
| pex11 | Spectrum | 4932 | -55.03 |
| kgd1 | Spectrum | 4932 | -54.66 |
| clb2 | Spectrum | 4932 | -54.16 |
| mad1 | Spectrum | 4932 | -53.94 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| HSP90 | ChEMBL | No stored yeast mapping |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| dnaB · Replicative DNA helicase DnaB | ChEMBL | No stored yeast mapping |
| HSP90AA1 · Heat shock protein HSP 90-alpha | ChEMBL | HSC82 YMR186W (ortholog_many2many); HSP82 YPL240C (ortholog_many2many) |
| NS1 · Nonstructural protein 1 | ChEMBL | No stored yeast mapping |
| RECQL · ATP-dependent DNA helicase Q1 | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| HSP90 | ChEMBL analogue | No stored yeast mapping |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL analogue | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| dnaB · Replicative DNA helicase DnaB | ChEMBL analogue | No stored yeast mapping |
| HSP90AA1 · Heat shock protein HSP 90-alpha | ChEMBL analogue | HSC82 YMR186W (ortholog_many2many); HSP82 YPL240C (ortholog_many2many) |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL analogue | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL analogue | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL analogue | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL analogue | No stored yeast mapping |
| RECQL · ATP-dependent DNA helicase Q1 | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| UBE2N · Ubiquitin-conjugating enzyme E2 N | ChEMBL analogue | No stored yeast mapping |
| VDR · Vitamin D3 receptor | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete MICONAZOLE NITRATE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.