CHEMGRID MOLECULE CARD
MECLIZINE HYDROCHLORIDE
MECLIZINE HYDROCHLORIDE in ChemGrid: 205 screened assays, 118 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500376
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500376
- Molecular formula
- C25Cl3H29N2
- InChIKey
- VCTHNOIYJIXQLV-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Meclozine Dihydrochloride
Stored SMILES
Cl.Cl.Cc1cccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)c1Matched external records: PubChem 64713
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 118 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| bck1 | SPECMTS3 | 4932 | -33.98 |
| SLT2 | Spectrum | 4932 | -29.98 |
| pep5 | SPECMTS3 | 4932 | -26.18 |
| MT2481-pdr1pdr3-2nd | SPECMTS3 | 4932 | -25.45 |
| ssb2 | SPECMTS3 | 4932 | -25.25 |
| faa2 | SPECMTS3 | 4932 | -24.20 |
| arl3 | SPECMTS3 | 4932 | -23.77 |
| vps1 | Spectrum | 4932 | -21.01 |
| rvs167 | Spectrum | 4932 | -19.60 |
| ccr4 | SPECMTS3 | 4932 | -19.47 |
| hhf1 | SPECMTS3 | 4932 | -18.25 |
| tpk1 | SPECMTS3 | 4932 | -18.21 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL | No stored yeast mapping |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL | No stored yeast mapping |
| fba · Fructose-bisphosphate aldolase | ChEMBL | SMI1 YGR229C (ortholog_one2many) |
| FTL · Ferritin light chain | ChEMBL | No stored yeast mapping |
| GBA1 · Lysosomal acid glucosylceramidase | ChEMBL | No stored yeast mapping |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL | No stored yeast mapping |
| NR1I3 · Nuclear receptor subfamily 1 group I member 3 | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| USP1 · Ubiquitin carboxyl-terminal hydrolase 1 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many); UBP8 YMR223W (ortholog_many2many); UBP2 YOR124C (ortholog_many2many) |
| VDR · Vitamin D3 receptor | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete MECLIZINE HYDROCHLORIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.