CHEMGRID MOLECULE CARD

LEUCOVORIN CALCIUM

LEUCOVORIN CALCIUM in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE01500364

Explore activity & SONAR

Chemical structure of LEUCOVORIN CALCIUM — Stored molecular structure

205Screened assays

0Significant assay responses

1Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE01500364
Molecular formula: C20CaH21N7O7
CAS registry number: 1492-18-8
InChIKey: KVUAALJSMIVURS-UHFFFAOYSA-L
Libraries: Spectrum, SPECMTS3, Spectrum_ED
Other recorded names: L-Glutamic acid,N-[4-[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-, calcium salt (1:1)

Stored SMILES

[Ca+2].[O-]C(=O)CCC(NC(=O)c1ccc(NCC2CNC3NC(N)=NC(=O)C=3N2C=O)cc1)C([O-])=O

Matched external records: PubChem 135430812

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
POLK · DNA polymerase kappa	ChEMBL	TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete LEUCOVORIN CALCIUM research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.