CHEMGRID MOLECULE CARD

ISONIAZID

ISONIAZID in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE01500355

Explore activity & SONAR

Chemical structure of ISONIAZID — Stored molecular structure

205Screened assays

0Significant assay responses

8Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE01500355
Molecular formula: C6H7N3O
CAS registry number: 54-85-3
InChIKey: QRXWMOHMRWLFEY-UHFFFAOYSA-N
Libraries: Spectrum, SPECMTS3, Spectrum_ED
Other recorded names: Isoniazid

Stored SMILES

NNC(=O)c1ccncc1

Matched external records: PubChem 3767

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
Luciferin 4-monooxygenase	ChEMBL	No stored yeast mapping
APEX1 · DNA repair nuclease/redox regulator APEX1	ChEMBL	No stored yeast mapping
CYP1A2 · Cytochrome P450 1A2	ChEMBL	No stored yeast mapping
CYP3A4 · Cytochrome P450 3A4	ChEMBL	No stored yeast mapping
folA · Dihydrofolate reductase	ChEMBL	No stored yeast mapping
GLS · Glutaminase kidney isoform, mitochondrial	ChEMBL	No stored yeast mapping
KDM4E · Lysine-specific demethylase 4E	ChEMBL	YJR119C (ortholog_one2many)
MPO · Myeloperoxidase	ChEMBL	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete ISONIAZID research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.