CHEMGRID MOLECULE CARD
IODOQUINOL
IODOQUINOL in ChemGrid: 205 screened assays, 204 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500353
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500353
- Molecular formula
- C9H5I2NO
- CAS registry number
- 83-73-8
- InChIKey
- UXZFQZANDVDGMM-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- 5,7-Diiodo-8-hydroxyquinoline
Stored SMILES
Oc1c(I)cc(I)c2cccnc12Matched external records: PubChem 3728
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 204 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| BY4743 | Spectrum_ED | 4932 | -73.48 |
| elg1 | Spectrum | 4932 | -57.05 |
| nat1 | SPECMTS3 | 4932 | -55.13 |
| BY4741-3rd | Spectrum_ED | 4932 | -54.43 |
| paf1 | SPECMTS3 | 4932 | -53.95 |
| tub3 | Spectrum | 4932 | -53.74 |
| set2 | Spectrum | 4932 | -53.19 |
| pex11 | Spectrum | 4932 | -52.92 |
| rbl2 | SPECMTS3 | 4932 | -52.79 |
| mad1 | Spectrum | 4932 | -52.76 |
| snc1 | SPECMTS3 | 4932 | -52.40 |
| CIN2 | Spectrum | 4932 | -52.10 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| HSP90 | ChEMBL | No stored yeast mapping |
| ACE · Angiotensin-converting enzyme | ChEMBL | No stored yeast mapping |
| ADORA3 · Adenosine receptor A3 | ChEMBL | No stored yeast mapping |
| FYN · Tyrosine-protein kinase Fyn | ChEMBL | No stored yeast mapping |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL | No stored yeast mapping |
| HSP90AA1 · Heat shock protein HSP 90-alpha | ChEMBL | HSC82 YMR186W (ortholog_many2many); HSP82 YPL240C (ortholog_many2many) |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MAPK14 · Mitogen-activated protein kinase 14 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| SLC6A2 · Sodium-dependent noradrenaline transporter | ChEMBL | No stored yeast mapping |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete IODOQUINOL research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.