CHEMGRID MOLECULE CARD

INDOPROFEN

INDOPROFEN in ChemGrid: 205 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE01500351

Explore activity & SONAR

Chemical structure of INDOPROFEN — Stored molecular structure

205Screened assays

1Significant assay responses

11Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE01500351
Molecular formula: C17H15NO3
CAS registry number: 31842-01-0
InChIKey: RJMIEHBSYVWVIN-UHFFFAOYSA-N
Libraries: Spectrum, SPECMTS3, Spectrum_ED
Other recorded names: Indoprofen

Stored SMILES

CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O

Matched external records: PubChem 3718

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
kre1	SPECMTS3	4932	-7.68

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
DRD1 · D(1A) dopamine receptor	ChEMBL	No stored yeast mapping
Fabp1 · Fatty acid-binding protein, liver	ChEMBL	No stored yeast mapping
GAA · Lysosomal alpha-glucosidase	ChEMBL	ROT2 YBR229C (ortholog_one2many)
HDAC6 · Protein deacetylase HDAC6	ChEMBL	HDA1 YNL021W (ortholog_one2one)
HTT · Huntingtin	ChEMBL	No stored yeast mapping
NFKB2 · Nuclear factor NF-kappa-B complex	ChEMBL	No stored yeast mapping
NPC1 · NPC intracellular cholesterol transporter 1	ChEMBL	NCR1 YPL006W (ortholog_one2one)
Ptgs1 · Prostaglandin G/H synthase 1	ChEMBL	No stored yeast mapping
RAB9A · Ras-related protein Rab-9A	ChEMBL	YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many)
Rorc · Nuclear receptor ROR-gamma	ChEMBL	No stored yeast mapping
SMN1 · Survival motor neuron protein	ChEMBL	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete INDOPROFEN research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.