CHEMGRID MOLECULE CARD
HISTAMINE DIHYDROCHLORIDE
HISTAMINE DIHYDROCHLORIDE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500331
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500331
- Molecular formula
- C5Cl2H11N3
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Histamine Dihydrochloride
Stored SMILES
Cl.Cl.NCCc1cncn1Matched external records: PubChem 5818
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| HRH2 · Histamine H2 receptor [CHEMBL1941] | ChEMBL | No stored yeast mapping |
| HRH2 · Histamine H2 receptor [CHEMBL2882] | ChEMBL | No stored yeast mapping |
| HRH3 · Histamine H3 receptor | ChEMBL | No stored yeast mapping |
| HRH4 · Histamine H4 receptor [CHEMBL3759] | ChEMBL | No stored yeast mapping |
| Hrh4 · Histamine H4 receptor [CHEMBL5657] | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL analogue | HDA1 YNL021W (ortholog_one2one) |
| HRH2 · Histamine H2 receptor | ChEMBL analogue | No stored yeast mapping |
| HRH3 · Histamine H3 receptor | ChEMBL analogue | No stored yeast mapping |
| Hrh4 · Histamine H4 receptor | ChEMBL analogue | No stored yeast mapping |
| MBD4 · Methyl-CpG-binding domain protein 4 | ChEMBL analogue | No stored yeast mapping |
| MPG · DNA-3-methyladenine glycosylase | ChEMBL analogue | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete HISTAMINE DIHYDROCHLORIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.