CHEMGRID MOLECULE CARD

GUAIFENESIN

GUAIFENESIN in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE01500321

Explore activity & SONAR

Chemical structure of GUAIFENESIN — Stored molecular structure

205Screened assays

0Significant assay responses

9Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE01500321
Molecular formula: C10H14O4
CAS registry number: 93-14-1
InChIKey: HSRJKNPTNIJEKV-UHFFFAOYSA-N
Libraries: Spectrum, SPECMTS3, Spectrum_ED
Other recorded names: Guaifenesin

Stored SMILES

COc1ccccc1OCC(O)CO

Matched external records: PubChem 3516

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
AGTR1 · Type-1 angiotensin II receptor	ChEMBL	No stored yeast mapping
ampC · Beta-lactamase	ChEMBL	No stored yeast mapping
CTRC · Chymotrypsin-C	ChEMBL	No stored yeast mapping
FEN1 · Flap endonuclease 1	ChEMBL	RAD27 YKL113C (ortholog_one2one)
GMNN · Geminin	ChEMBL	No stored yeast mapping
HDAC6 · Protein deacetylase HDAC6	ChEMBL	HDA1 YNL021W (ortholog_one2one)
HRH2 · Histamine H2 receptor	ChEMBL	No stored yeast mapping
MDH1 · Malate dehydrogenase, cytoplasmic	ChEMBL	No stored yeast mapping
RAPGEF3 · Rap guanine nucleotide exchange factor 3	ChEMBL	LTE1 YAL024C (ortholog_many2many); CDC25 YLR310C (ortholog_many2many)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete GUAIFENESIN research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.