CHEMGRID MOLECULE CARD

ESTRIOL

ESTRIOL in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE01500285

Explore activity & SONAR

Chemical structure of ESTRIOL — Stored molecular structure

205Screened assays

0Significant assay responses

8Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE01500285
Molecular formula: C18H24O3
InChIKey: PROQIPRRNZUXQM-UHFFFAOYSA-N
Libraries: Spectrum, SPECMTS3, Spectrum_ED
Other recorded names: 13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta(a)phenanthrene-3,16,17-triol

Stored SMILES

CC12CCC3C(CCc4cc(O)ccc34)C1CC(O)C2O

Matched external records: PubChem 3269

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
ampC · Beta-lactamase	ChEMBL	No stored yeast mapping
ATAD5 · ATPase family AAA domain-containing protein 5	ChEMBL	No stored yeast mapping
NFE2L2 · Nuclear factor erythroid 2-related factor 2	ChEMBL	No stored yeast mapping
PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor	ChEMBL	No stored yeast mapping
AR · Androgen receptor	ChEMBL analogue	No stored yeast mapping
KAT2A · Histone acetyltransferase KAT2A	ChEMBL analogue	BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many)
NR3C1 · Glucocorticoid receptor	ChEMBL analogue	No stored yeast mapping
POLK · DNA polymerase kappa	ChEMBL analogue	TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete ESTRIOL research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.