CHEMGRID MOLECULE CARD
DIOXYBENZONE
DIOXYBENZONE in ChemGrid: 616 screened assays, 116 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500255
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500255
- Molecular formula
- C14H12O4
- CAS registry number
- 131-53-3
- InChIKey
- MEZZCSHVIGVWFI-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, SpectrumTMP, Spectrum_ED
- Other recorded names
- 2,2'-Dihydroxy-4-methoxybenzophenone
Stored SMILES
COc1ccc(c(O)c1)C(=O)c1ccccc1OMatched external records: PubChem 8569
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
616 measurements across 616 distinct library–species–strain assays; 116 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| bem2 | SPECMTS3 | 4932 | -16.34 |
| ypt6 | SPECMTS3 | 4932 | -15.10 |
| rgp1 | SPECMTS3 | 4932 | -14.87 |
| bck1 | SPECMTS3 | 4932 | -13.91 |
| arl3 | SPECMTS3 | 4932 | -12.74 |
| lat1 | SPECMTS3 | 4932 | -12.25 |
| vps1 | Spectrum | 4932 | -11.50 |
| tpk1 | SPECMTS3 | 4932 | -9.74 |
| vph1 | SPECMTS3 | 4932 | -9.58 |
| spt3 | SPECMTS3 | 4932 | -9.54 |
| doc1 | SPECMTS3 | 4932 | -9.39 |
| mms22 | SPECMTS3 | 4932 | -9.29 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADORA3 · Adenosine receptor A3 | ChEMBL | No stored yeast mapping |
| AR · Androgen receptor | ChEMBL | No stored yeast mapping |
| CHRM1 · Muscarinic acetylcholine receptor M1 | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| CYP2C19 · Cytochrome P450 2C19 | ChEMBL | DIT2 YDR402C (ortholog_one2many) |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL | No stored yeast mapping |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| TBXA2R · Thromboxane A2 receptor | ChEMBL | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| CBX1 · Chromobox protein homolog 1 | ChEMBL analogue | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL analogue | No stored yeast mapping |
| CYP2C19 · Cytochrome P450 2C19 | ChEMBL analogue | DIT2 YDR402C (ortholog_one2many) |
| GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ChEMBL analogue | GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many) |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL analogue | AYR1 YIL124W (ortholog_one2one) |
| HTT · Huntingtin | ChEMBL analogue | No stored yeast mapping |
| Lipe · Hormone-sensitive lipase | ChEMBL analogue | No stored yeast mapping |
| RORC · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| SLC6A2 · Sodium-dependent noradrenaline transporter | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete DIOXYBENZONE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.