CHEMGRID MOLECULE CARD
DIFLUNISAL
DIFLUNISAL in ChemGrid: 205 screened assays, 20 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500245
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500245
- Molecular formula
- C13F2H8O3
- CAS registry number
- 22494-42-4
- InChIKey
- HUPFGZXOMWLGNK-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Diflunisal
Stored SMILES
OC(=O)c1cc(ccc1O)c1ccc(F)cc1FMatched external records: PubChem 3059
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 20 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| BY4743 | Spectrum_ED | 4932 | -9.72 |
| nup100 | Spectrum | 4932 | -9.02 |
| BY4741-3rd | Spectrum_ED | 4932 | -6.38 |
| kar3 | Spectrum | 4932 | -6.38 |
| BY4741-2nd | Spectrum_ED | 4932 | -6.08 |
| mdh1 | Spectrum | 4932 | -5.93 |
| YKL085W | Spectrum | 4932 | -5.93 |
| kgd1 | Spectrum | 4932 | -5.87 |
| tfp1 | Spectrum | 4932 | -5.78 |
| cla4 | Spectrum | 4932 | -5.43 |
| srl3 | SPECMTS3 | 4932 | -5.20 |
| clb2 | Spectrum | 4932 | -4.94 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Luciferin 4-monooxygenase | ChEMBL | No stored yeast mapping |
| ACMSD · 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| CA1 · Carbonic anhydrase 1 | ChEMBL | No stored yeast mapping |
| CA2 · Carbonic anhydrase 2 | ChEMBL | No stored yeast mapping |
| CXCL12 · Stromal cell-derived factor 1 | ChEMBL | No stored yeast mapping |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| SLC22A6 · Solute carrier family 22 member 6 | ChEMBL | PHO84 YML123C (ortholog_one2many) |
| TTR · Transthyretin | ChEMBL | No stored yeast mapping |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| ACMSD · 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| CA1 · Carbonic anhydrase 1 | ChEMBL analogue | No stored yeast mapping |
| CA2 · Carbonic anhydrase 2 | ChEMBL analogue | No stored yeast mapping |
| CXCL12 · Stromal cell-derived factor 1 | ChEMBL analogue | No stored yeast mapping |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| SLC22A6 · Solute carrier family 22 member 6 | ChEMBL analogue | PHO84 YML123C (ortholog_one2many) |
| TTR · Transthyretin | ChEMBL analogue | No stored yeast mapping |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL analogue | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete DIFLUNISAL research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.