CHEMGRID MOLECULE CARD
CLOTRIMAZOLE
CLOTRIMAZOLE in ChemGrid: 205 screened assays, 204 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500200
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500200
- Molecular formula
- C22ClH17N2
- CAS registry number
- 23593-75-1
- InChIKey
- VNFPBHJOKIVQEB-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Clotrimazole
Stored SMILES
Clc1ccccc1C(n1ccnc1)(c1ccccc1)c1ccccc1Matched external records: PubChem 2812
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 204 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| BY4743 | Spectrum_ED | 4932 | -74.40 |
| nup100 | Spectrum | 4932 | -62.14 |
| elg1 | Spectrum | 4932 | -59.05 |
| BY4741 | SPECMTS3 | 4932 | -57.76 |
| nat1 | SPECMTS3 | 4932 | -56.03 |
| tub3 | Spectrum | 4932 | -55.90 |
| set2 | Spectrum | 4932 | -55.10 |
| pex11 | Spectrum | 4932 | -55.04 |
| paf1 | SPECMTS3 | 4932 | -54.92 |
| BY4741-3rd | Spectrum_ED | 4932 | -54.26 |
| clb2 | Spectrum | 4932 | -53.95 |
| mad1 | Spectrum | 4932 | -53.93 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| cyp121 · Mycocyclosin synthase | ChEMBL | No stored yeast mapping |
| CYP17A1 · Steroid 17-alpha-hydroxylase/17,20 lyase | ChEMBL | No stored yeast mapping |
| CYP19A1 · Aromatase | ChEMBL | No stored yeast mapping |
| CYP2C19 · Cytochrome P450 2C19 | ChEMBL | DIT2 YDR402C (ortholog_one2many) |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL | No stored yeast mapping |
| CYP3A4 · Cytochrome P450 3A4 | ChEMBL | No stored yeast mapping |
| KCNN4 · Intermediate conductance calcium-activated potassium channel protein 4 | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| NR1I3 · Nuclear receptor subfamily 1 group I member 3 | ChEMBL | No stored yeast mapping |
| TBXAS1 · Thromboxane-A synthase | ChEMBL | No stored yeast mapping |
| cyp121 · Mycocyclosin synthase | ChEMBL analogue | No stored yeast mapping |
| CYP17A1 · Steroid 17-alpha-hydroxylase/17,20 lyase | ChEMBL analogue | No stored yeast mapping |
| CYP19A1 · Aromatase | ChEMBL analogue | No stored yeast mapping |
| CYP2C19 · Cytochrome P450 2C19 | ChEMBL analogue | DIT2 YDR402C (ortholog_one2many) |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL analogue | No stored yeast mapping |
| CYP3A4 · Cytochrome P450 3A4 | ChEMBL analogue | No stored yeast mapping |
| KCNN4 · Intermediate conductance calcium-activated potassium channel protein 4 | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| NR1I3 · Nuclear receptor subfamily 1 group I member 3 | ChEMBL analogue | No stored yeast mapping |
| TBXAS1 · Thromboxane-A synthase | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete CLOTRIMAZOLE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.