CHEMGRID MOLECULE CARD
CHLOROQUINE DIPHOSPHATE
CHLOROQUINE DIPHOSPHATE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500179
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500179
- Molecular formula
- C18ClH32N3O8P2
- CAS registry number
- 54-05-7
- InChIKey
- QKICWELGRMTQCR-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
Stored SMILES
CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12.OP(O)(O)=O.OP(O)(O)=OChemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Histidine-rich protein PFHRP-II | ChEMBL | No stored yeast mapping |
| NSD1 · Histone-lysine N-methyltransferase, H3 lysine-36 specific | ChEMBL | SET1 YHR119W (ortholog_many2many); SET2 YJL168C (ortholog_many2many) |
| ACE2 · Angiotensin-converting enzyme 2 | ChEMBL analogue | No stored yeast mapping |
| ADRA1D · Alpha-1D adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| CHRM2 · Muscarinic acetylcholine receptor M2 | ChEMBL analogue | No stored yeast mapping |
| CHRM3 · Muscarinic acetylcholine receptor M3 | ChEMBL analogue | No stored yeast mapping |
| CHRM4 · Muscarinic acetylcholine receptor M4 | ChEMBL analogue | No stored yeast mapping |
| SIGMAR1 · Sigma non-opioid intracellular receptor 1 | ChEMBL analogue | No stored yeast mapping |
| TLR7 · Toll-like receptor 7 | ChEMBL analogue | No stored yeast mapping |
| TLR9 · Toll-like receptor 9 | ChEMBL analogue | No stored yeast mapping |
| TMEM97 · Sigma intracellular receptor 2 | ChEMBL analogue | YLR050C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete CHLOROQUINE DIPHOSPHATE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.