CHEMGRID MOLECULE CARD
CHLOROCRESOL
CHLOROCRESOL in ChemGrid: 205 screened assays, 6 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500178
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500178
- Molecular formula
- C7ClH7O
- CAS registry number
- 59-50-7
- InChIKey
- CFKMVGJGLGKFKI-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- 4-Chloro-3-methylphenol
Stored SMILES
Cc1cc(O)ccc1ClMatched external records: PubChem 1732
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 6 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| sac3 | SPECMTS3 | 4932 | -6.28 |
| ref2 | SPECMTS3 | 4932 | 5.86 |
| ypt6 | SPECMTS3 | 4932 | -5.20 |
| rgp1 | SPECMTS3 | 4932 | -4.79 |
| sto1 | SPECMTS3 | 4932 | 4.61 |
| ccr4 | SPECMTS3 | 4932 | 4.50 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ATP2A1 · Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | ChEMBL | ENA5 YDR038C (ortholog_many2many); ENA2 YDR039C (ortholog_many2many); ENA1 YDR040C (ortholog_many2many); CCC2 YDR270W (ortholog_many2many); PMA1 YGL008C (ortholog_many2many); PMR1 YGL167C (ortholog_many2many); PMA2 YPL036W (ortholog_many2many) |
| fba · Fructose-bisphosphate aldolase | ChEMBL | SMI1 YGR229C (ortholog_one2many) |
| FTL · Ferritin light chain | ChEMBL | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL | HDA1 YNL021W (ortholog_one2one) |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL | No stored yeast mapping |
| NR3C1 · Glucocorticoid receptor | ChEMBL | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| RORC · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| USP1 · Ubiquitin carboxyl-terminal hydrolase 1 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many); UBP8 YMR223W (ortholog_many2many); UBP2 YOR124C (ortholog_many2many) |
| ADRA1A · Alpha-1A adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL analogue | No stored yeast mapping |
| CHRM1 · Muscarinic acetylcholine receptor M1 | ChEMBL analogue | No stored yeast mapping |
| fba · Fructose-bisphosphate aldolase | ChEMBL analogue | SMI1 YGR229C (ortholog_one2many) |
| FTL · Ferritin light chain | ChEMBL analogue | No stored yeast mapping |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| HTR2B · 5-hydroxytryptamine receptor 2B | ChEMBL analogue | No stored yeast mapping |
| MAOA · Amine oxidase [flavin-containing] A | ChEMBL analogue | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL analogue | No stored yeast mapping |
| PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor | ChEMBL analogue | No stored yeast mapping |
| Slc18a2 · Synaptic vesicular amine transporter | ChEMBL analogue | TPO2 YGR138C (ortholog_many2many); TPO3 YPR156C (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete CHLOROCRESOL research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.