CHEMGRID MOLECULE CARD
AMILORIDE HYDROCHLORIDE
AMILORIDE HYDROCHLORIDE in ChemGrid: 616 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01500112
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01500112
- Molecular formula
- C6Cl2H9N7O
- InChIKey
- ACHKKGDWZVCSNH-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, SpectrumTMP, Spectrum_ED
- Other recorded names
- Amiloride hydrochloride anhydrous
Stored SMILES
Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1NMatched external records: PubChem 16230
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
616 measurements across 616 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| YPT6 | Spectrum | 4932 | 4.14 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Trypsin | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| ERG · Transcriptional regulator ERG | ChEMBL | No stored yeast mapping |
| ESR1 · Estrogen receptor | ChEMBL | No stored yeast mapping |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| MTOR · Serine/threonine-protein kinase mTOR | ChEMBL | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL | No stored yeast mapping |
| Nr1i2 · Nuclear receptor subfamily 1 group I member 2 | ChEMBL | No stored yeast mapping |
| SMPD1 · Sphingomyelin phosphodiesterase | ChEMBL | PPN1 YDR452W (ortholog_one2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| ATXN2 · Ataxin-2 | ChEMBL analogue | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL analogue | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| ERG · Transcriptional regulator ERG | ChEMBL analogue | No stored yeast mapping |
| ESR1 · Estrogen receptor | ChEMBL analogue | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| MTOR · Serine/threonine-protein kinase mTOR | ChEMBL analogue | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL analogue | No stored yeast mapping |
| nfo · Endonuclease 4 | ChEMBL analogue | No stored yeast mapping |
| Nr1i2 · Nuclear receptor subfamily 1 group I member 2 | ChEMBL analogue | No stored yeast mapping |
| RAD52 · DNA repair protein RAD52 homolog | ChEMBL analogue | RAD59 YDL059C (ortholog_one2many); RAD52 YML032C (ortholog_one2many) |
| SMPD1 · Sphingomyelin phosphodiesterase | ChEMBL analogue | PPN1 YDR452W (ortholog_one2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
First 30 of 31 target records; open the interactive profile for further evidence.
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete AMILORIDE HYDROCHLORIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.