CHEMGRID MOLECULE CARD
CRESOPYRINE
CRESOPYRINE in ChemGrid: 192 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01401414
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01401414
- Molecular formula
- C10H10O4
- CAS registry number
- 4386-39-4
- InChIKey
- XRBMKGUDDJPAMH-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3
- Other recorded names
- Cresopirine
Stored SMILES
CC(=O)Oc1c(C)cccc1C(O)=OMatched external records: PubChem 78094
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
192 measurements across 192 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL | HDA1 YNL021W (ortholog_one2one) |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| HMGB1 · High mobility group protein B1 | ChEMBL analogue | No stored yeast mapping |
| NAPRT · Nicotinate phosphoribosyltransferase | ChEMBL analogue | NPT1 YOR209C (ortholog_one2many) |
| PTGS1 · Prostaglandin G/H synthase 1 | ChEMBL analogue | No stored yeast mapping |
| TSHR · Thyrotropin receptor | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete CRESOPYRINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.