CHEMGRID MOLECULE CARD
4-NONYLPHENOL
4-NONYLPHENOL in ChemGrid: 205 screened assays, 196 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00330085
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00330085
- Molecular formula
- C15H24O
- CAS registry number
- 25154-52-3
- InChIKey
- IGFHQQFPSIBGKE-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- 4-Nonylphenol
Stored SMILES
CCCCCCCCCc1ccc(O)cc1Matched external records: PubChem 1752
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 196 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| BY4743 | Spectrum_ED | 4932 | -75.19 |
| BY4741 | SPECMTS3 | 4932 | -57.68 |
| BY4741-3rd | Spectrum_ED | 4932 | -57.13 |
| nat1 | SPECMTS3 | 4932 | -54.60 |
| paf1 | SPECMTS3 | 4932 | -54.56 |
| hsp104 | SPECMTS3 | 4932 | -54.00 |
| snc1 | SPECMTS3 | 4932 | -53.50 |
| rbl2 | SPECMTS3 | 4932 | -52.96 |
| hsp82 | SPECMTS3 | 4932 | -52.63 |
| srl3 | SPECMTS3 | 4932 | -52.54 |
| sdh2 | SPECMTS3 | 4932 | -52.13 |
| gyp1 | SPECMTS3 | 4932 | -51.68 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADORA3 · Adenosine receptor A3 | ChEMBL | No stored yeast mapping |
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL | No stored yeast mapping |
| ATP2A1 · Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | ChEMBL | ENA5 YDR038C (ortholog_many2many); ENA2 YDR039C (ortholog_many2many); ENA1 YDR040C (ortholog_many2many); CCC2 YDR270W (ortholog_many2many); PMA1 YGL008C (ortholog_many2many); PMR1 YGL167C (ortholog_many2many); PMA2 YPL036W (ortholog_many2many) |
| Atp2a2 · Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | ChEMBL | ENA5 YDR038C (ortholog_many2many); ENA2 YDR039C (ortholog_many2many); ENA1 YDR040C (ortholog_many2many); CCC2 YDR270W (ortholog_many2many); PMA1 YGL008C (ortholog_many2many); PMR1 YGL167C (ortholog_many2many); YOR291W (ortholog_many2many); PMA2 YPL036W (ortholog_many2many) |
| Atp2a3 · Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | ChEMBL | ENA5 YDR038C (ortholog_many2many); ENA2 YDR039C (ortholog_many2many); ENA1 YDR040C (ortholog_many2many); PMA1 YGL008C (ortholog_many2many); PMA2 YPL036W (ortholog_many2many) |
| ESR1 · Estrogen receptor | ChEMBL | No stored yeast mapping |
| HTR2C · 5-hydroxytryptamine receptor 2C | ChEMBL | No stored yeast mapping |
| SHBG · Sex hormone-binding globulin | ChEMBL | No stored yeast mapping |
| SLC6A2 · Sodium-dependent noradrenaline transporter | ChEMBL | No stored yeast mapping |
| SLC6A3 · Sodium-dependent dopamine transporter | ChEMBL | No stored yeast mapping |
| SLC6A4 · Sodium-dependent serotonin transporter | ChEMBL | No stored yeast mapping |
| TACR2 · Substance-K receptor | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 4-NONYLPHENOL research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.