CHEMGRID MOLECULE CARD
MITOTANE
MITOTANE in ChemGrid: 205 screened assays, 8 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00330082
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00330082
- Molecular formula
- C14Cl4H10
- CAS registry number
- 53-19-0
- InChIKey
- JWBOIMRXGHLCPP-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Mitotane
Stored SMILES
ClC(Cl)C(c1ccc(Cl)cc1)c1ccccc1ClMatched external records: PubChem 4211
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 8 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| MT2481-pdr1pdr3-2nd | SPECMTS3 | 4932 | -24.41 |
| qcr8 | SPECMTS3 | 4932 | -7.22 |
| aat2 | SPECMTS3 | 4932 | -5.89 |
| trk1 | SPECMTS3 | 4932 | -5.31 |
| mrc1 | SPECMTS3 | 4932 | -4.69 |
| lat1 | SPECMTS3 | 4932 | -4.56 |
| pdr_yCG196 | Spectrum_ED | 4932 | -4.17 |
| atp4 | SPECMTS3 | 4932 | -4.14 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ACAT1 · Acetyl-CoA acetyltransferase, mitochondrial | ChEMBL | No stored yeast mapping |
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL | No stored yeast mapping |
| Ar · Androgen receptor | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| HTR2B · 5-hydroxytryptamine receptor 2B | ChEMBL | No stored yeast mapping |
| HTR6 · 5-hydroxytryptamine receptor 6 | ChEMBL | No stored yeast mapping |
| NR3C1 · Glucocorticoid receptor | ChEMBL | No stored yeast mapping |
| PGR · Progesterone receptor | ChEMBL | No stored yeast mapping |
| SLC6A2 · Sodium-dependent noradrenaline transporter | ChEMBL | No stored yeast mapping |
| SLC6A3 · Sodium-dependent dopamine transporter | ChEMBL | No stored yeast mapping |
| SLC6A4 · Sodium-dependent serotonin transporter | ChEMBL | No stored yeast mapping |
| ACAT1 · Acetyl-CoA acetyltransferase, mitochondrial | ChEMBL analogue | No stored yeast mapping |
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| Ar · Androgen receptor | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| HTR2B · 5-hydroxytryptamine receptor 2B | ChEMBL analogue | No stored yeast mapping |
| HTR6 · 5-hydroxytryptamine receptor 6 | ChEMBL analogue | No stored yeast mapping |
| NR3C1 · Glucocorticoid receptor | ChEMBL analogue | No stored yeast mapping |
| PGR · Progesterone receptor | ChEMBL analogue | No stored yeast mapping |
| SLC6A2 · Sodium-dependent noradrenaline transporter | ChEMBL analogue | No stored yeast mapping |
| SLC6A3 · Sodium-dependent dopamine transporter | ChEMBL analogue | No stored yeast mapping |
| SLC6A4 · Sodium-dependent serotonin transporter | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete MITOTANE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.