CHEMGRID MOLECULE CARD
PROPAZINE
PROPAZINE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00330026
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00330026
- Molecular formula
- C9ClH16N5
- CAS registry number
- 139-40-2
- InChIKey
- WJNRPILHGGKWCK-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Propazine
Stored SMILES
CC(C)Nc1nc(Cl)nc(NC(C)C)n1Matched external records: PubChem 4937
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| FTL · Ferritin light chain | ChEMBL | No stored yeast mapping |
| GAA · Lysosomal alpha-glucosidase | ChEMBL | ROT2 YBR229C (ortholog_one2many) |
| GLP1R · Glucagon-like peptide 1 receptor | ChEMBL | No stored yeast mapping |
| POLK · DNA polymerase kappa | ChEMBL | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| THRB · Thyroid hormone receptor beta | ChEMBL | No stored yeast mapping |
| Chloroplast thylakoid membrane protein (psbA) | ChEMBL analogue | No stored yeast mapping |
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| GLP1R · Glucagon-like peptide 1 receptor | ChEMBL analogue | No stored yeast mapping |
| GLS · Glutaminase kidney isoform, mitochondrial | ChEMBL analogue | No stored yeast mapping |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| petD · Cytochrome b6-f complex subunit 4 | ChEMBL analogue | No stored yeast mapping |
| POLI · DNA polymerase iota | ChEMBL analogue | No stored yeast mapping |
| PPARD · Peroxisome proliferator-activated receptor delta | ChEMBL analogue | No stored yeast mapping |
| PPX1 · Protoporphyrinogen IX oxidase | ChEMBL analogue | No stored yeast mapping |
| psbA · Photosystem Q(B) protein | ChEMBL analogue | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete PROPAZINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.