CHEMGRID MOLECULE CARD
RHAMNETIN
RHAMNETIN in ChemGrid: 192 screened assays, 72 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00310031
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00310031
- Molecular formula
- C16H12O7
- CAS registry number
- 90-19-7
- InChIKey
- JGUZGNYPMHHYRK-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3
- Other recorded names
- Rhamnetin
Stored SMILES
COc1cc(O)c2C(=O)C(O)=C(Oc2c1)c1ccc(O)c(O)c1Matched external records: PubChem 5281691
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
192 measurements across 192 distinct library–species–strain assays; 72 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| fet3 | SPECMTS3 | 4932 | -31.55 |
| ssb2 | SPECMTS3 | 4932 | -30.10 |
| rpn1 | SPECMTS3 | 4932 | -22.88 |
| ccr4 | SPECMTS3 | 4932 | -22.76 |
| arl3 | SPECMTS3 | 4932 | -22.58 |
| doa4 | SPECMTS3 | 4932 | -21.12 |
| faa2 | SPECMTS3 | 4932 | -18.81 |
| vam3 | SPECMTS3 | 4932 | -18.01 |
| fks1 | SPECMTS3 | 4932 | -15.61 |
| chs3 | SPECMTS3 | 4932 | -14.18 |
| kem1 | SPECMTS3 | 4932 | -14.02 |
| drs2 | SPECMTS3 | 4932 | -13.91 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| AKR1B1 · Aldo-keto reductase family 1 member B1 | ChEMBL | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| APP · Amyloid-beta precursor protein | ChEMBL | No stored yeast mapping |
| ELAVL3 · ELAV-like protein 3 | ChEMBL | No stored yeast mapping |
| IP6K2 · Inositol hexakisphosphate kinase 2 | ChEMBL | No stored yeast mapping |
| POLK · DNA polymerase kappa | ChEMBL | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| RECQL · ATP-dependent DNA helicase Q1 | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| ABCG2 · Broad substrate specificity ATP-binding cassette transporter ABCG2 | ChEMBL analogue | SNQ2 YDR011W (ortholog_many2many); PDR15 YDR406W (ortholog_many2many); PDR11 YIL013C (ortholog_many2many); YNR070W (ortholog_many2many); AUS1 YOR011W (ortholog_many2many); PDR5 YOR153W (ortholog_many2many); PDR10 YOR328W (ortholog_many2many); PDR12 YPL058C (ortholog_many2many) |
| ACHE · Acetylcholinesterase | ChEMBL analogue | No stored yeast mapping |
| AKR1B1 · Aldo-keto reductase family 1 member B1 | ChEMBL analogue | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| CDK1 · Cyclin-dependent kinase 1/cyclin B | ChEMBL analogue | CDC28 YBR160W (ortholog_one2many) |
| CDK5 · Cyclin-dependent kinase 5/CDK5 activator 1 | ChEMBL analogue | No stored yeast mapping |
| CDK6 · Cyclin-dependent kinase 6 | ChEMBL analogue | No stored yeast mapping |
| CSNK2A1 · Casein kinase II subunit alpha | ChEMBL analogue | CKA1 YIL035C (ortholog_many2many); CKA2 YOR061W (ortholog_many2many) |
| Csnk2b · Casein kinase 2 | ChEMBL analogue | No stored yeast mapping |
| CSNK2B · Casein kinase II | ChEMBL analogue | No stored yeast mapping |
| CYP19A1 · Aromatase | ChEMBL analogue | No stored yeast mapping |
| CYP1B1 · Cytochrome P450 1B1 | ChEMBL analogue | No stored yeast mapping |
| F2 · Prothrombin | ChEMBL analogue | No stored yeast mapping |
| fabI · Enoyl-acyl-carrier protein reductase | ChEMBL analogue | No stored yeast mapping |
| GSK3A · Glycogen synthase kinase-3 | ChEMBL analogue | No stored yeast mapping |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL analogue | No stored yeast mapping |
| Impa1 · Inositol monophosphatase 1 | ChEMBL analogue | No stored yeast mapping |
| MAOA · Amine oxidase [flavin-containing] A | ChEMBL analogue | No stored yeast mapping |
| MBNL1 · Muscleblind-like protein 1 | ChEMBL analogue | No stored yeast mapping |
| Nt5e · 5'-nucleotidase | ChEMBL analogue | YHR202W (ortholog_one2one) |
| PIK3CA · Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | ChEMBL analogue | No stored yeast mapping |
| PIM1 · Serine/threonine-protein kinase pim-1 | ChEMBL analogue | PIM1 YBL022C (ortholog_one2many) |
| PKM · Pyruvate kinase PKM | ChEMBL analogue | CDC19 YAL038W (ortholog_many2many); PYK2 YOR347C (ortholog_many2many) |
First 30 of 36 target records; open the interactive profile for further evidence.
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete RHAMNETIN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.