CHEMGRID MOLECULE CARD

SANTONIN

SANTONIN in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE00300542

Explore activity & SONAR

Chemical structure of SANTONIN — Stored molecular structure

205Screened assays

0Significant assay responses

1Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE00300542
Molecular formula: C15H18O3
CAS registry number: 481-06-1
InChIKey: XJHDMGJURBVLLE-UHFFFAOYSA-N
Libraries: Spectrum, SPECMTS3, Spectrum_ED
Other recorded names: 3,5a,9-Trimethyl-3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione

Stored SMILES

CC1C2CCC3(C)C=CC(=O)C(C)=C3C2OC1=O

Matched external records: PubChem 5156

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
ALOX5 · Polyunsaturated fatty acid 5-lipoxygenase	ChEMBL	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete SANTONIN research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.