CHEMGRID MOLECULE CARD
SCANDENIN
SCANDENIN in ChemGrid: 512 screened assays, 309 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00300348
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00300348
- Molecular formula
- C26H26O6
- InChIKey
- AAKJUGSASOCUFQ-UHFFFAOYSA-N
- Libraries
- Spectrum, SpectrumTMP
- Other recorded names
- Scandenin
Stored SMILES
COc1c(CC=C(C)C)c2OC(C)(C)C=Cc2c2OC(=O)C(=C(O)c12)c1ccc(O)cc1Matched external records: PubChem 54676535
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
512 measurements across 512 distinct library–species–strain assays; 309 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| CYC24h | SpectrumTMP | 4932 | -37.57 |
| CRA21h | SpectrumTMP | 4932 | -37.56 |
| CAN24h | SpectrumTMP | 4932 | -37.38 |
| FEN24h | SpectrumTMP | 4932 | -36.74 |
| CRA24h | SpectrumTMP | 4932 | -35.04 |
| mBUT18 | SpectrumTMP | 4932 | -34.25 |
| MT2481-pdr1pdr3-2nd | Spectrum | 4932 | -33.44 |
| m4ATP18 | SpectrumTMP | 4932 | -30.70 |
| mFEN18 | SpectrumTMP | 4932 | -28.35 |
| MT2481-pdr1pdr3 | Spectrum | 4932 | -27.45 |
| HAL24h | SpectrumTMP | 4932 | -27.09 |
| PEU21h | SpectrumTMP | 4932 | -26.28 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| POLK · DNA polymerase kappa | ChEMBL | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| USP1 · Ubiquitin carboxyl-terminal hydrolase 1 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many); UBP8 YMR223W (ortholog_many2many); UBP2 YOR124C (ortholog_many2many) |
| VDR · Vitamin D3 receptor | ChEMBL | No stored yeast mapping |
| USP1 · Ubiquitin carboxyl-terminal hydrolase 1 | ChEMBL analogue | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many); UBP8 YMR223W (ortholog_many2many); UBP2 YOR124C (ortholog_many2many) |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL analogue | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete SCANDENIN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.