CHEMGRID MOLECULE CARD
4--METHOXYFLAVONE
4--METHOXYFLAVONE in ChemGrid: 205 screened assays, 159 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00240958
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00240958
- Molecular formula
- C16H12O3
- CAS registry number
- 4143-74-2
- InChIKey
- OMICQBVLCVRFGN-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- 4`-METHOXYFLAVONE; 4'-Methoxyflavone
Stored SMILES
COc1ccc(cc1)C1Oc2ccccc2C(=O)C=1Matched external records: PubChem 77793
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 159 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| mck1 | Spectrum | 4932 | -36.81 |
| SLT2 | Spectrum | 4932 | -29.70 |
| lat1 | SPECMTS3 | 4932 | -25.69 |
| vps1 | Spectrum | 4932 | -25.65 |
| cnb1-2nd | Spectrum | 4932 | -23.25 |
| tif3 | Spectrum | 4932 | -21.56 |
| bem2 | SPECMTS3 | 4932 | -21.10 |
| mms22 | SPECMTS3 | 4932 | -18.13 |
| NBP2 | Spectrum | 4932 | -18.09 |
| CIN8 | Spectrum | 4932 | -17.90 |
| Arp1 | Spectrum | 4932 | -17.14 |
| ser1 | Spectrum | 4932 | -16.54 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Luciferin 4-monooxygenase | ChEMBL | No stored yeast mapping |
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| AR · Androgen receptor | ChEMBL | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL | No stored yeast mapping |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL | NCR1 YPL006W (ortholog_one2one) |
| NR0B1 · Nuclear receptor subfamily 0 group B member 1 | ChEMBL | No stored yeast mapping |
| POLK · DNA polymerase kappa | ChEMBL | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| Ptgs2 · Prostaglandin G/H synthase 2 | ChEMBL | No stored yeast mapping |
| RAB9A · Ras-related protein Rab-9A | ChEMBL | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| TNKS · Poly [ADP-ribose] polymerase tankyrase-1 | ChEMBL | No stored yeast mapping |
| TP53 · Cellular tumor antigen p53 | ChEMBL | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| Avian myoblastosis virus polyprotein II | ChEMBL analogue | No stored yeast mapping |
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| ABCB1 · ATP-dependent translocase ABCB1 | ChEMBL analogue | MDL1 YLR188W (ortholog_many2many); MDL2 YPL270W (ortholog_many2many) |
| ACHE · Acetylcholinesterase | ChEMBL analogue | No stored yeast mapping |
| AKR1B1 · Aldo-keto reductase family 1 member B1 | ChEMBL analogue | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL analogue | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| ampC · Beta-lactamase | ChEMBL analogue | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL analogue | No stored yeast mapping |
| BRCA1 · Breast cancer type 1 susceptibility protein | ChEMBL analogue | No stored yeast mapping |
| CA12 · Carbonic anhydrase 12 | ChEMBL analogue | No stored yeast mapping |
| CA4 · Carbonic anhydrase 4 | ChEMBL analogue | No stored yeast mapping |
| CA7 · Carbonic anhydrase 7 | ChEMBL analogue | No stored yeast mapping |
| CBR1 · Carbonyl reductase [NADPH] 1 | ChEMBL analogue | YIR035C (ortholog_many2many); YIR036C (ortholog_many2many) |
First 30 of 70 target records; open the interactive profile for further evidence.
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 4--METHOXYFLAVONE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.