CHEMGRID MOLECULE CARD
3-HYDROXYCOUMARIN
3-HYDROXYCOUMARIN in ChemGrid: 192 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00211538
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00211538
- Molecular formula
- C9H6O3
- CAS registry number
- 939-19-5
- InChIKey
- MJKVTPMWOKAVMS-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3
- Other recorded names
- 3-Hydroxycoumarin
Stored SMILES
OC1=Cc2ccccc2OC1=OMatched external records: PubChem 13650
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
192 measurements across 192 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| top1-2nd | Spectrum | 4932 | 4.29 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| AKR1B1 · Aldo-keto reductase family 1 member B1 | ChEMBL | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| DAO · D-amino-acid oxidase | ChEMBL | No stored yeast mapping |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| PPO2 · Mushroom tyrosinase | ChEMBL | No stored yeast mapping |
| SORD · Sorbitol dehydrogenase | ChEMBL | BDH1 YAL060W (ortholog_many2many); YAL061W (ortholog_many2many); YBL068W-A (ortholog_many2many); AST1 YBL069W (ortholog_many2many); YCR102C (ortholog_many2many); ADH7 YCR105W (ortholog_many2many); AST2 YER101C (ortholog_many2many); YLR460C (ortholog_many2many); ADH6 YMR318C (ortholog_many2many); YNL134C (ortholog_many2many) |
| TYR · Tyrosinase | ChEMBL | No stored yeast mapping |
| XDH · Xanthine dehydrogenase/oxidase | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 3-HYDROXYCOUMARIN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.