CHEMGRID MOLECULE CARD
5,4`-DIMETHOXYFLAVONE
5,4`-DIMETHOXYFLAVONE in ChemGrid: 101 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00211227
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00211227
- Molecular formula
- C17H14O4
- InChIKey
- LUCPCQIWHDVLMX-UHFFFAOYSA-N
- Libraries
- Spectrum
- Other recorded names
- 5,4'-Dimethoxyflavone
Stored SMILES
COc1ccc(cc1)C1Oc2cccc(OC)c2C(=O)C=1Matched external records: PubChem 688669
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
101 measurements across 101 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Ptgs2 · Prostaglandin G/H synthase 2 | ChEMBL | No stored yeast mapping |
| Avian myoblastosis virus polyprotein II | ChEMBL analogue | No stored yeast mapping |
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| ABCB1 · ATP-dependent translocase ABCB1 | ChEMBL analogue | MDL1 YLR188W (ortholog_many2many); MDL2 YPL270W (ortholog_many2many) |
| ABCC1 · Multidrug resistance-associated protein 1 | ChEMBL analogue | No stored yeast mapping |
| ACHE · Acetylcholinesterase | ChEMBL analogue | No stored yeast mapping |
| AKR1B1 · Aldo-keto reductase family 1 member B1 | ChEMBL analogue | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL analogue | No stored yeast mapping |
| BRCA1 · Breast cancer type 1 susceptibility protein | ChEMBL analogue | No stored yeast mapping |
| CA12 · Carbonic anhydrase 12 | ChEMBL analogue | No stored yeast mapping |
| CA4 · Carbonic anhydrase 4 | ChEMBL analogue | No stored yeast mapping |
| CA7 · Carbonic anhydrase 7 | ChEMBL analogue | No stored yeast mapping |
| CBR1 · Carbonyl reductase [NADPH] 1 | ChEMBL analogue | YIR035C (ortholog_many2many); YIR036C (ortholog_many2many) |
| CDK8 · Cyclin-dependent kinase 8 | ChEMBL analogue | No stored yeast mapping |
| CDK9 · Cyclin-dependent kinase 9 | ChEMBL analogue | SGV1 YPR161C (ortholog_one2one) |
| CSNK2B · Casein kinase 2 | ChEMBL analogue | No stored yeast mapping |
| CYP19A1 · Aromatase | ChEMBL analogue | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL analogue | No stored yeast mapping |
| CYP1B1 · Cytochrome P450 1B1 | ChEMBL analogue | No stored yeast mapping |
| CYP2C19 · Cytochrome P450 2C19 | ChEMBL analogue | DIT2 YDR402C (ortholog_one2many) |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL analogue | No stored yeast mapping |
| DPP4 · Dipeptidyl peptidase 4 | ChEMBL analogue | DAP2 YHR028C (ortholog_one2one) |
| ESR2 · Estrogen receptor beta | ChEMBL analogue | No stored yeast mapping |
| FLT3 · Receptor-type tyrosine-protein kinase FLT3 | ChEMBL analogue | No stored yeast mapping |
| GLP1R · Glucagon-like peptide 1 receptor | ChEMBL analogue | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL analogue | HDA1 YNL021W (ortholog_one2one) |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL analogue | No stored yeast mapping |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL analogue | No stored yeast mapping |
| IP6K2 · Inositol hexakisphosphate kinase 2 | ChEMBL analogue | No stored yeast mapping |
| IPMK · Inositol polyphosphate multikinase | ChEMBL analogue | No stored yeast mapping |
First 30 of 47 target records; open the interactive profile for further evidence.
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 5,4`-DIMETHOXYFLAVONE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.