CHEMGRID MOLECULE CARD
DIPHENYLUREA
DIPHENYLUREA in ChemGrid: 616 screened assays, 6 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00211126
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00211126
- Molecular formula
- C13H12N2O
- CAS registry number
- 102-07-8
- InChIKey
- GWEHVDNNLFDJLR-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, SpectrumTMP, Spectrum_ED
- Other recorded names
- Carbanilide
Stored SMILES
O=C(Nc1ccccc1)Nc1ccccc1Matched external records: PubChem 7595
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
616 measurements across 616 distinct library–species–strain assays; 6 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| SMI1 | Spectrum | 4932 | 11.47 |
| top1-2nd | Spectrum | 4932 | 9.46 |
| BRE1 | Spectrum | 4932 | 5.08 |
| TOP1 | Spectrum | 4932 | 4.74 |
| spo22 | Spectrum | 4932 | 4.68 |
| ric1 | Spectrum | 4932 | 4.66 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Epoxide hydrolase B | ChEMBL | No stored yeast mapping |
| AHR · Aryl hydrocarbon receptor | ChEMBL | No stored yeast mapping |
| AKT1 · RAC-alpha serine/threonine-protein kinase | ChEMBL | No stored yeast mapping |
| AKT2 · RAC-beta serine/threonine-protein kinase | ChEMBL | No stored yeast mapping |
| AKT3 · RAC-gamma serine/threonine-protein kinase | ChEMBL | No stored yeast mapping |
| AURKA · Aurora kinase A | ChEMBL | No stored yeast mapping |
| CDK9 · Cyclin-dependent kinase 9 | ChEMBL | SGV1 YPR161C (ortholog_one2one) |
| CLK4 · Dual specificity protein kinase CLK4 | ChEMBL | YAK1 YJL141C (ortholog_many2many); KNS1 YLL019C (ortholog_many2many) |
| CSF1R · Macrophage colony-stimulating factor 1 receptor | ChEMBL | No stored yeast mapping |
| EPHX1 · Epoxide hydrolase 1 | ChEMBL | No stored yeast mapping |
| EPHX2 · Bifunctional epoxide hydrolase 2 | ChEMBL | YBR204C (ortholog_many2many); YGR110W (ortholog_many2many) |
| MAPK14 · Mitogen-activated protein kinase 14 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| Nr1i2 · Nuclear receptor subfamily 1 group I member 2 | ChEMBL | No stored yeast mapping |
| PIM1 · Serine/threonine-protein kinase pim-1 | ChEMBL | PIM1 YBL022C (ortholog_one2many) |
| PLK4 · Serine/threonine-protein kinase PLK4 | ChEMBL | No stored yeast mapping |
| PRKCQ · Protein kinase C theta type | ChEMBL | No stored yeast mapping |
| SYK · Tyrosine-protein kinase SYK | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete DIPHENYLUREA research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.