CHEMGRID MOLECULE CARD
PYROGALLIN
PYROGALLIN in ChemGrid: 192 screened assays, 125 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00210515
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00210515
- Molecular formula
- C11H8O4
- InChIKey
- OLSYHLURTGEIBH-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3
- Other recorded names
- 1,2,8-Trihydroxybenzo[7]annulen-9-one
Stored SMILES
Oc1ccc2C=CC=C(O)C(=O)c2c1OMatched external records: PubChem 137631326
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
192 measurements across 192 distinct library–species–strain assays; 125 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| KRE1 | Spectrum | 4932 | -48.80 |
| PPZ1 | Spectrum | 4932 | -46.73 |
| CIN2 | Spectrum | 4932 | -44.86 |
| VPS5 | Spectrum | 4932 | -44.81 |
| CNB1 | Spectrum | 4932 | -44.42 |
| DEP1 | Spectrum | 4932 | -38.90 |
| CIN8 | Spectrum | 4932 | -38.07 |
| BY4741 | Spectrum | 4932 | -37.81 |
| SLT2 | Spectrum | 4932 | -37.40 |
| ndi1 | SPECMTS3 | 4932 | -36.66 |
| mad1 | Spectrum | 4932 | -36.30 |
| Arp1 | Spectrum | 4932 | -35.61 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CDK2 · Cyclin-dependent kinase 2 | ChEMBL | No stored yeast mapping |
| PTPN11 · Tyrosine-protein phosphatase non-receptor type 11 | ChEMBL | PTP3 YER075C (ortholog_many2many) |
| Tlr2 · Toll-like receptor 1/2 | ChEMBL | No stored yeast mapping |
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL analogue | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| CASP6 · Caspase-6 | ChEMBL analogue | No stored yeast mapping |
| CASP7 · Caspase-7 | ChEMBL analogue | No stored yeast mapping |
| Dyrk1a · Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ChEMBL analogue | No stored yeast mapping |
| L3MBTL1 · Lethal(3)malignant brain tumor-like protein 1 | ChEMBL analogue | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL analogue | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| mex-5 · Zinc finger protein mex-5 | ChEMBL analogue | No stored yeast mapping |
| NSD2 · Histone-lysine N-methyltransferase NSD2 | ChEMBL analogue | No stored yeast mapping |
| pol · Human immunodeficiency virus type 1 integrase | ChEMBL analogue | No stored yeast mapping |
| POLB · DNA polymerase beta | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete PYROGALLIN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.